About Me

I work in the Division of Oncology and McDonnell Genome Institute at Washington University in St. Louis, where I develop and apply computational tools to give us insight into the origins and progression of cancer.

My core research interests include:

  • Cancer - studying the genomic alterations that result in tumorigenesis
  • The clonal architecture of tumors and how they evolve in response to therapy
  • Integrative analysis to place genomic aberrations into a functional context
  • Effective design and targeting of cancer immunotherapies
  • Developing open-source software for integrating, mining, and visualizing genomic data
  • Utilizing online technologies to drive science communication and collaboration

  • Education


    Publications


    * denotes shared first authorship

    Presentations

    • Tumor Heterogeneity and Evolution
      Genomics in Medicine Seminar Series (2019)
    • Characterizing genomic responses to cancer immunotherapy
      Genome Informatics (2016)
    • Genomic insights into tumor evolution and therapy response
      Festival of Genomics Boston (2016)
    • Assessing tumor heterogeneity and tracking clonal clearance in response to therapy
      Genome Informatics (2015)
    • Ultra-deep whole-genome sequencing reveals clinically relevant low-frequency subclones in an acute myeloid leukemia
      The Cancer Genome Atlas Symposium (2014)
    • SciClone: Inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolution and therapy resistance
      Personal Genomes & Pharmacogenomics (2013)
    • Multi-dimensional clustering of mutations from heterogeneous tumors offers insight into clonal architecture, tumor evolution, and response to therapy
      The Cancer Genome Atlas Steering Committee Meeting (2013)
    • Assessing Tumor Heterogeneity and Tracking Clonal Evolution Using Whole Genome or Exome Sequencing
      The Cancer Genome Atlas Scientific Symposium (2012) link
    • An Image Analytic Approach to Characterizing Vasculogenic Networks
      Presentation: Truman State University Student Research Symposium (2005)

    Teaching

    • Lecturer - High-Throughput Biology: From Sequence to Networks - CSHL/CBW Course (2019)
    • WUSTL Bioinformatics Workshops (2017-2019)
      • Workshop Co-organizer
      • Lectures on Bash, Docker/LSF/HPC, DNA Alignment, Variant Calling
    • Lecturer - Human Genetics (2019)
    • Lecturer - Computational Statistical Genetics (2017-19)
    • Lecturer - Investigating Eukaryotic Genomes (2015-2017)
    • Lecturer - Molecular Basis of Heredity (2015)
    • Computer Aided Discovery Methods (2007 and 2008)
      co-developer of the course and taught computational labs on:
      • Studies of genome variation
      • Transcriptional regulatory pathways
    • Computational Mathematics for Biomedical Scientists (2008)
      • Teaching Assistant
    • Advanced Topics: Quantitative Biology (2005)
      • Teaching Assistant

    Editorial

    Ad-hoc reviewer for Bioinformatics, Cancer Cell, Genome Biology, PLoS Computational Biology, Nucleic Acids Research, Nature Communications, BMC Evolutionary Biology.
    Grant reviewer for Dutch Cancer Society (KWF Kankerbestrijding)